No seizures yet thank goodness, but he is drinking a ton of water. How old was your pup? Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. Today he wont eat, is sleeping all day, and when he is up he is panting heavily. Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. Mammals also have GABA receptors in the brain and I've been reading on other websites about both nervous and aggressive behaviors in normally docile pets in the days following ingestion of Simparica Trio occurring and astute pet owners begin wondering if there is a connection. Will never use again. I lost my previous bichon poo to seizures 2 years ago and I dont want to go through that type of pain and lost again! Our two year old dog took the same thing and thank god she has no symptoms. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). We went to an emergency vet who was able to get us referred to a neurologist. He has never acted like he was in pain. I wish I read about this particular product before giving it to my dog because now I'm worried he may get more symptoms. After reading all your entries, i'm thrilled i chose to take her off of it. I am so beyond mad, what can I do to get this out of her system and better yet what can we do to get this product off the market. These signs usually resolve without treatment. Linda. And urinating more often as a result. I need to tell my vet to switch! gave this to my dog three different times. They both got similar issues and this was the only thing they both did. Kind of ooze. For those who lost their dear companions from this medicine my heart goes out to you all. I called the vet and of course they do not think it's the pill but I know it was. Neurological reactions: In rare cases, dogs may exhibit tremors, ataxia (loss of coordination), or seizures as a side effect of the medication. so what about her puppies I am so worried. A week ago I gave him Trifexis because he had been on it a few years ago.the next night he had a seizure. Update June 7th. I am sure simparica caused a fatal seizure in my boxer. That sh-t should be banned. For me, Simparica Trio has made parasite control effective and easyI just give her one chewable tablet each month. My dog was under the 6 month mark that most dogs start idiopathic epilepsy, he could not have had a history. Four months of vet visits because of one dose of field tested safe Simparica. The Simparica chewable is a poor choice for dogs with a history of prior seizures. I wanted to investigate a bit before dosing him. All went well until this morning. She went on 2 antibiotics, and medicated baths twice a week. Overly anxious. He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. Thanks all for sharing your experiences. Stopped meds and he has had 3 more seizures since. I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. She is lethargic and doesnt want to eat. He has no appetite and very little drinking either so hes not using the bathroom much. I have a completely different dog. It has been five days and the diarrhea started on day 2. First time for this adverse reaction. He's a 1 1/2 y.o. By the evening she lost the use of her hind legs. I take her everywhere as I'm terrified of it happening and her dying, we were convinced she was dying. He was in excellent health prior to this incident. She couldnt walk straight anymore and stopped eating. She is absolutely miserable and we're hoping she makes it. Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs. There is a possibility it isn't the cause, but it is the only reason I can find and it aligns with the stories of others. She nearly died. No problem eating. I'll be spreading the word. (On Monday, she fell down several times in an hour. Also I read on Dr Mercola site that heartworms is in the dogs blood not the digestive track and garlic won't work. Heartworm medicine alone should be ok. Oh my god I'm so glad I found this group. Im beside myself with guilt and fear. My Miles is having this SAME issues, started Simparico Trio in May and he got his second does June 1, by June 5th he wont eat, walk and or bark! Discuss Simparica chewable treats with your veterinarian when looking for a safe, effective way to arm your dog against biting parasites and the diseases they carry. Side effects include: vomiting, diarrhea, lethargy, anorexia, otitis externa (ear. Are there any side effects of using Simparica TRIO for the dog? I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). Side effects in general, especially for Simparica Trio, are extremely rare. Simparica has an active ingredient called Sarolaner. Argh. I've beaten myself up so much giving her this drug, I felt I could trust the vet and the drug company but we obviously cant and it's all about making more money. I sure hope we don't have ongoing problems. These are: Twitching and muscle tremors. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. If it was due to the Simparica, then it would expected to be resolved within a day or two. The company is reimbursing for vet costs. Gave our pup of 10 years the Simparica Trio as suggested by our vet 1 week ago instead of the Simparica and Interceptor he had been on for 7 years with no problems. It is recommended that all pets be tested for existing heartworm infection prior to starting treatment with Simparica Trio. This medicine is making her shaky/tremor, anxious, and she is panting a ton. It works by creating uncontrolled neuromuscular activity leading to death in fleas as well as some ticks and mites. The vet has not been able to diagnose a cause. I dont know what to do to get this out of their system?? He has been on just Simparica with no problems. I have had German Shepherds for 40 yrs. Our vet recommended putting him on phenobarbital. My husband said , get dressed were taking him in . I have 3 other dogs - large breeds that also took 1 dose, but no reaction. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. Seizures. No running or jumping, Continuously wandering around the fence line of the back yard. Now that Ive read all these comments I think he has developed these issues because of this trio medication. Head down, facing the wall, tremors, lethargic, and she can't seem to see well. My dog is having the same issues. Chewable tablets can be given directly to your dog or broken up and mixed with food. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. I am so mad at myself for letting the vet talk me into this. Not drinking any water but drooling and swallowing all the time. Hearing 35-40 to leave systems. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without occurrence of any side effects. Daily Paws is part of the Meredith National Digital Network. The only thing we changed after his checkup if Feb. was his flea and tick treatment. Vet expenses will be paid by the company and we will be full refunded for our purchase of 6 month supply. But few people read it or think it must be a million to one problem. Our baby isnt the same at all since his one and only dose of Simparica. Is the added expense worth the trouble to insure your beloved pet? Again he has diarrhea and this month he seems agitated or nervous. Today really soft stool (not diarrhea but close). The whole packet is going in the bin !! I took him to the energy vet in the morning, he couldnt find any cause for pain, only he yelped a bit on his neck, they had trouble getting him in, he was yanking his neck around as he is afraid of the vet since getting fixed. now seizures daily on all sorts of meds for it and the cost with medications to try and control seizures and vet visits and mainly seeing my once healthy playful full of life pups having seizures daily even in her sleep breaks my damn heart !!!!!!!!!!!!!! And both of my other labs, basically house dogs, ended up with a droopy left eye. 1 dose of this Simperica Trio and he is completely different and cant hold his pee. After spending the day at the ER Vet where they did bloodwork and several x-rays all coming back normal, they sent her home with Keppra. he didn't throw up but he doesn't want to go to bed at night and he just paces around the bedroom and sometimes goes under the bed. Our Vet suggested Simparica Trio! Vet said they dont think it has anything to do with the Simparica. I PRAY that our baby is okay with this second dose. Simparica has been approved by the FDA to treat and prevent flea and tick infestations. He is scared of his own shadow at night (this may be him loosing his eyesight slowly) but now Im putting two and two together and all this started happening more and more after he started this medicine last year in May. I will never give my dog this medication again. I am very worried I called the vet they said oops sorry they made a mistake. Zoetis (Simparica, Simparica Trio, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see How to Report Animal Drug and Device Side Effects and Product Problems. Getting him to go out was nearly impossible. Another possibility would be that the dosage was to high for her (simparica comes in three different dosages). I would not recommend giving Simparica to your pets!!!!! Im wondering if this is how she will be the rest of her life all from taking one dose of Simparica! Since then I've researched loads and as you say the FDA put out a report. My last one lived to almost 15yrs old and I truly believe it was because I had him on Springtime Garlic tabs. A month later, he was at doggie daycare and we picked him up and he was panting frantically. Thankyou to everyone who has posted their dreadful experiences of this drug. I have ordered what I normally use and will throw this in the trash! For the next 3-4 days I noticed he would be a bit hesitant to jump or hop around and play as he normally does (and his appetite was lower than usual). I fed him a diet of boiled chicken and rice for 3 days and began to introduce his food which is a limited ingredient type. I gave my black lab mix Simparica for the 1st time on 4/1. My 9 month old puppy started acting very lethargic after taking simparica trio. This may post twice - I didn't see my original post so I'm trying again! Then they come back! I sadly started my beautiful dog on Simparica Trio on May 1, 2021. Will not be using this treatment again!!! Then giving more drugs for itching. I hope it is better. After second pill, weve notice he has been a bit down for a couple days. I thought maybe he got into something. Especially after seeing these post. I got my dog Josey up to let him out to pee. Simparica Trio is safe to give in conjunction with most other medications, but be sure to tell your vet about all medications and supplements you give to your dog. I have been telling everyone not to give this to their furry ones!!!!!!!! I will post an update 7 days later. She vomited twice and became so lethargic that she couldnt walk. There was no clear diagnosis but it was clearly neurological. Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. I feel so sad for you Camelia. Her poor top underside of her tail has raw skin the hair is completely gone like burnt off from diarrhea. Back to the vet and I hope they credit my money. I hope there will be a class action lawsuit but most importantly that the word get out to stop this medication from harming another life. I hate that I did this to her and I hate that the Vet does not seem to care. 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